USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: EZRI_HUMAN USC-OGP 2-DE database:  EZRI_HUMAN EZRI_HUMAN General information about the entry View entry in simple text format Entry name EZRI_HUMAN Primary accession number P15311 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Ezrin; AltName: Full=Cytovillin; AltName: Full=Villin-2; AltName: Full=p81;. Gene name Name=EZR Synonyms=VIL2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1120: pI=6.09; Mw=84978 Cross-references UniProtKB/Swiss-Prot P15311; EZRI_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name EZRI_HUMAN Primary accession number P15311 Secondary accession number(s) E1P5A8 P23714 Q4VX75 Q96CU8 Q9NSJ4 Sequence was last modified on  February 6, 2007 (version 4) Annotations were last modified on  March 15, 2017 (version 194) Name and origin of the protein Description RecName: Full=Ezrin; AltName: Full=Cytovillin; AltName: Full=Villin-2; AltName: Full=p81; Gene name Name=EZR Synonyms=VIL2 Encoded on Name=EZR; Synonyms=VIL2 Keywords 3D-structure; Acetylation; Cell membrane; Cell projection; Cell shape; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Polymorphism; Reference proteome; S-nitrosylation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X51521; CAA35893.1; -; mRNA EMBL J05021; AAA61278.1; ALT_INIT; mRNA EMBL AL162086; CAB82418.1; ALT_INIT; mRNA EMBL AL589931; CAI95307.1; -; Genomic_DNA EMBL CH471051; EAW47647.1; -; Genomic_DNA EMBL BC013903; AAH13903.1; -; mRNA CCDS CCDS5258.1; -; . PIR A34400; A34400; . RefSeq NP_001104547.1; NM_001111077.1; . RefSeq NP_003370.2; NM_003379.4; . UniGene Hs.487027; -; . PDB 1NI2; X-ray; 2.30 A; A/B=2-297 PDB 4RM8; X-ray; 1.90 A; A/B=1-586 PDB 4RM9; X-ray; 2.00 A; A=1-586 PDB 4RMA; X-ray; 1.75 A; A/B=1-296 PDBsum 1NI2; -; . PDBsum 4RM8; -; . PDBsum 4RM9; -; . PDBsum 4RMA; -; . DisProt DP00775; -; . ProteinModelPortal P15311; -; . SMR P15311; -; . BioGrid 113271; 144; . DIP DIP-38868N; -; . IntAct P15311; 38; . MINT MINT-195721; -; . STRING 9606.ENSP00000338934; -; . BindingDB P15311; -; . ChEMBL CHEMBL1932896; -; . iPTMnet P15311; -; . PhosphoSitePlus P15311; -; . SwissPalm P15311; -; . BioMuta EZR; -; . DMDM 125987826; -; . DOSAC-COBS-2DPAGE P15311; -; . REPRODUCTION-2DPAGE IPI00843975; -; . SWISS-2DPAGE P15311; -; . EPD P15311; -; . MaxQB P15311; -; . PaxDb P15311; -; . PeptideAtlas P15311; -; . PRIDE P15311; -; . TopDownProteomics P15311; -; . DNASU 7430; -; . Ensembl ENST00000337147; ENSP00000338934; ENSG00000092820; . Ensembl ENST00000367075; ENSP00000356042; ENSG00000092820; . GeneID 7430; -; . KEGG hsa:7430; -; . UCSC uc003qrt.5; human; . CTD 7430; -; . DisGeNET 7430; -; . GeneCards EZR; -; . HGNC HGNC:12691; EZR; . HPA CAB004035; -; . HPA CAB047324; -; . HPA HPA021616; -; . MalaCards EZR; -; . MIM 123900; gene; . neXtProt NX_P15311; -; . OpenTargets ENSG00000092820; -; . PharmGKB PA162385512; -; . eggNOG KOG3529; Eukaryota; . eggNOG ENOG410XQFP; LUCA; . GeneTree ENSGT00860000133686; -; . HOGENOM HOG000007113; -; . HOVERGEN HBG002185; -; . InParanoid P15311; -; . KO K08007; -; . PhylomeDB P15311; -; . TreeFam TF313935; -; . Reactome R-HSA-373752; Netrin-1 signaling; . Reactome R-HSA-437239; Recycling pathway of L1; . SIGNOR P15311; -; . ChiTaRS EZR; human; . EvolutionaryTrace P15311; -; . GeneWiki Ezrin; -; . GenomeRNAi 7430; -; . PRO PR:P15311; -; . Proteomes UP000005640; Chromosome 6; . Bgee ENSG00000092820; -; . CleanEx HS_EZR; -; . ExpressionAtlas P15311; baseline and differential; . Genevisible P15311; HS; . GO GO:0015629; C:actin cytoskeleton; IDA:UniProtKB; . GO GO:0005884; C:actin filament; IDA:HGNC; . GO GO:0045177; C:apical part of cell; IDA:BHF-UCL; . GO GO:0016324; C:apical plasma membrane; IDA:UniProtKB; . GO GO:0097449; C:astrocyte projection; IEA:Ensembl; . GO GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB; . GO GO:0005903; C:brush border; ISS:UniProtKB; . GO GO:0044297; C:cell body; IEA:Ensembl; . GO GO:0071944; C:cell periphery; IDA:UniProtKB; . GO GO:0042995; C:cell projection; IDA:UniProtKB; . GO GO:0051286; C:cell tip; IEA:Ensembl; . GO GO:0036064; C:ciliary basal body; IEA:Ensembl; . GO GO:0030863; C:cortical cytoskeleton; TAS:HGNC; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0098592; C:cytoplasmic side of apical plasma membrane; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0005768; C:endosome; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0019898; C:extrinsic component of membrane; IDA:UniProtKB; . GO GO:0001650; C:fibrillar center; IDA:HPA; . GO GO:0030175; C:filopodium; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0001772; C:immunological synapse; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0044393; C:microspike; IEA:Ensembl; . GO GO:0005902; C:microvillus; IDA:BHF-UCL; . GO GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IDA:UniProtKB; . GO GO:0044853; C:plasma membrane raft; IDA:UniProtKB; . GO GO:0001726; C:ruffle; IDA:UniProtKB; . GO GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell; . GO GO:0097454; C:Schwann cell microvillus; IEA:Ensembl; . GO GO:0030315; C:T-tubule; IEA:Ensembl; . GO GO:0001931; C:uropod; IEA:Ensembl; . GO GO:0031982; C:vesicle; IDA:UniProtKB; . GO GO:0003779; F:actin binding; IDA:UniProtKB; . GO GO:0051015; F:actin filament binding; IDA:UniProtKB; . GO GO:0051117; F:ATPase binding; IPI:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0050839; F:cell adhesion molecule binding; IPI:BHF-UCL; . GO GO:0008017; F:microtubule binding; IMP:UniProtKB; . GO GO:0019904; F:protein domain specific binding; IPI:UniProtKB; . GO GO:0034236; F:protein kinase A catalytic subunit binding; IPI:UniProtKB; . GO GO:0034237; F:protein kinase A regulatory subunit binding; IPI:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0044548; F:S100 protein binding; IPI:UniProtKB; . GO GO:0031532; P:actin cytoskeleton reorganization; IMP:UniProtKB; . GO GO:0051017; P:actin filament bundle assembly; IDA:UniProtKB; . GO GO:0030953; P:astral microtubule organization; IMP:UniProtKB; . GO GO:0007411; P:axon guidance; TAS:Reactome; . GO GO:0034629; P:cellular protein complex localization; IMP:UniProtKB; . GO GO:0071320; P:cellular response to cAMP; IMP:UniProtKB; . GO GO:0043622; P:cortical microtubule organization; IMP:UniProtKB; . GO GO:0007016; P:cytoskeletal anchoring at plasma membrane; NAS:UniProtKB; . GO GO:0051660; P:establishment of centrosome localization; IMP:UniProtKB; . GO GO:0061028; P:establishment of endothelial barrier; IGI:UniProtKB; . GO GO:0090002; P:establishment of protein localization to plasma membrane; IMP:UniProtKB; . GO GO:0035088; P:establishment or maintenance of apical/basal cell polarity; IEA:Ensembl; . GO GO:0046847; P:filopodium assembly; IMP:UniProtKB; . GO GO:0001951; P:intestinal D-glucose absorption; IEA:Ensembl; . GO GO:0007159; P:leukocyte cell-cell adhesion; IEP:BHF-UCL; . GO GO:0022614; P:membrane to membrane docking; IEP:BHF-UCL; . GO GO:0030033; P:microvillus assembly; IMP:UniProtKB; . GO GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:UniProtKB; . GO GO:1900041; P:negative regulation of interleukin-2 secretion; IMP:UniProtKB; . GO GO:1903753; P:negative regulation of p38MAPK cascade; IMP:UniProtKB; . GO GO:0050860; P:negative regulation of T cell receptor signaling pathway; IMP:UniProtKB; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB; . GO GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:UniProtKB; . GO GO:1903364; P:positive regulation of cellular protein catabolic process; IGI:UniProtKB; . GO GO:2000643; P:positive regulation of early endosome to late endosome transport; IMP:UniProtKB; . GO GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; IEA:Ensembl; . GO GO:0010628; P:positive regulation of gene expression; IGI:UniProtKB; . GO GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl; . GO GO:1902966; P:positive regulation of protein localization to early endosome; IGI:UniProtKB; . GO GO:0050714; P:positive regulation of protein secretion; IMP:UniProtKB; . GO GO:0010737; P:protein kinase A signaling; IMP:UniProtKB; . GO GO:0072697; P:protein localization to cell cortex; IMP:UniProtKB; . GO GO:0031623; P:receptor internalization; IEA:Ensembl; . GO GO:0008360; P:regulation of cell shape; IMP:UniProtKB; . GO GO:0032532; P:regulation of microvillus length; IEA:Ensembl; . GO GO:1902115; P:regulation of organelle assembly; IMP:UniProtKB; . GO GO:0003376; P:sphingosine-1-phosphate signaling pathway; IMP:UniProtKB; . GO GO:1902896; P:terminal web assembly; IEA:Ensembl; . Gene3D 1.20.80.10; -; 1; . Gene3D 2.30.29.30; -; 1; . InterPro IPR019749; Band_41_domain; . InterPro IPR011174; ERM; . InterPro IPR011259; ERM_C_dom; . InterPro IPR000798; Ez/rad/moesin-like; . InterPro IPR014352; FERM/acyl-CoA-bd_prot_3-hlx; . InterPro IPR019748; FERM_central; . InterPro IPR019747; FERM_CS; . InterPro IPR000299; FERM_domain; . InterPro IPR018979; FERM_N; . InterPro IPR018980; FERM_PH-like_C; . InterPro IPR008954; Moesin_tail; . InterPro IPR011993; PH_dom-like; . InterPro IPR029071; Ubiquitin-rel_dom; . Pfam PF00769; ERM; 1; . Pfam PF09380; FERM_C; 1; . Pfam PF00373; FERM_M; 1; . Pfam PF09379; FERM_N; 1; . PIRSF PIRSF002305; ERM; 1; . PRINTS PR00935; BAND41; . PRINTS PR00661; ERMFAMILY; . SMART SM00295; B41; 1; . SMART SM01196; FERM_C; 1; . SUPFAM SSF47031; SSF47031; 1; . SUPFAM SSF48678; SSF48678; 1; . SUPFAM SSF50729; SSF50729; 1; . SUPFAM SSF54236; SSF54236; 1; . PROSITE PS00660; FERM_1; 1; . PROSITE PS00661; FERM_2; 1; . PROSITE PS50057; FERM_3; 1; .

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